Publications
Cockey JR and Leifer CA. Racing CARs to Veterinary Immuno-oncology. 2023 Front Vet Sci Vol 10 https://doi.org/10.3389/fvets.2023.1130182
Gruber EJ, Aygun AY, Leifer CA.. Macrophage uptake of oxidized and acetylated low-density lipoproteins and generation of reactive oxygen species are regulated by linear stiffness of the growth surface. 2021 PLoS One. Dec 16;16(12):e0260756. doi: 10.1371/journal.pone.0260756.
Gruber EJ, Leifer CA. Molecular regulation of TLR signaling in health and disease: mechano-regulation of macrophages and TLR signaling.
2020 Innate Immun. Jan;26(1):15-25. doi: 10.1177/1753425919838322.
Mosquera MJ, Kim S, Zhou H, Jing TT, Luna M, Guss JD, Reddy P, Lai K, Leifer CA, Brito IL, Hernandez CJ, Singh A. Immunomodulatory nanogels overcome restricted immunity in a murine model of gut microbiome-mediated metabolic syndrome. 2019. Sci Adv. 5(3):eaav9788. doi: 10.1126/sciadv.aav9788.
Li S, , Walter WA, Chassing B, Zhang B, Shi Q, Waters J, Gewirtz AT, Leifer CA ,Ley RE. Gut microbiota influence B cell function in a TLR5-dependent manner. 2019 BioRXiV doi: doi.org/10.1101/537894.
Singel KL, Grzankowski KS, Khan ANMNH, Grimm MJ, D'Auria AC, Morrell K, Eng KH, Hylander B, Mayor PC, Emmons TR, Lénárt N, Fekete R, Környei Z, Muthukrishnan U, Gilthorpe JD, Urban CF, Itagaki K, Hauser CJ, Leifer C, Moysich KB, Odunsi K, Dénes Á, Segal BH. Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer. 2019 Br J Cancer. 120(2):207-217. doi: 10.1038/s41416-018-0339-8.
Gruber, EJ, Heyward C, Cameron, JL, Leifer, CA. TLR signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled coil kinase (ROCK1/2). 2018 Int Immunol. 30(6):267-278. doi: 10.1093/intimm/dxy027.
Heyward C, Sones J, Lob H, Yeun L, Abbott K, Huang W, Begun Z, Butler S, August A, Leifer C, Davisson RL. 2017. The decídua of BPH/5 preeclamptic-like mice exhibits an exaggerated inflammatory response during early pregnancy, J Repro Immunology 120:27-33.
Watkins HC, Rappazzo CG, Higgins JS, Sun X, Brock N, Chau A, Misra A, Cannizzo JP, King MR, Maines TR, Leifer CA, Whittaker GR, DeLisa MP, Putnam D. 2017 Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection. Mol Ther. S1525-0016(17)30016-3.
Phan TL, Pritchett JC, Leifer CA, Zerr DM, Koelle DM, Di Luca D, Lusso P. HHV-6B infection, T-cell reconstitution, and graft-vs-host disease after hematopoietic stem cell transplantation. 2018 Bone Marrow Transplant. 53(12):1508-1517 doi: 10.1038/s41409-018-0225-2.
Londono R, Dziki JL, Haljasmaa E, Turner NJ, Leifer CA, Badylak SF. The effect of cell debris within biologic scaffolds upon the macrophage response. 2017 J Biomed Mater Res A. 105(8):2109-2118.
Heyward CY, Sones JL, Lob HE, Yuen LC, Abbott KE, Huang W, Begun ZR, Butler SD, August A, Leifer CA, Davisson RL. The decidua of preeclamptic-like BPH/5 mice exhibits an exaggerated inflammatory response during early pregnancy. 2017 J Reprod Immunol. 120:27-33. .
Watkins HC, Rappazzo CG, Higgins JS, Sun X, Brock N, Chau A, Misra A, Cannizzo JP, King MR, Maines TR, Leifer CA, Whittaker GR, DeLisa MP, Putnam D. Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection. 2017 Mol Ther. 25(4):989-1002.
CA Leifer. Dendritic cells in host response to biologic scaffolds. 2017 Semin Immunol. 29:41-48.
Leifer CA, Medvedev AE. Molecular mechanisms of regulation of Toll-like receptor signaling. 2016 J Leukoc Biol. 2016 100(5):927-941.
Sinha SS, Cameron JL, Brooks JC, Leifer CA. Complex Negative Regulation of TLR9 by Multiple Proteolytic Cleavage Events. J Immunol. 2016 Aug 15;197(4):1343-52.
Hasan M, Gruber E, Cameron J, Leifer CA. TLR9 stability and signaling are regulated by phosphorylation and cell stress. J Leukoc Biol. 2016 Sep;100(3):525-33.
Rappazzo CG, Watkins HC, Guarino CM, Chau A, Lopez JL, DeLisa MP, Leifer CA, Whittaker GR, Putnam D. 2016. Recombinant M2e outer membrane vessicle vaccines protect against lethal influenza A challenge in BALB/c mice. Vaccine 34:1252-1258.
Patel H, Patel P, Ochiana S, Yan P, Sun W, Patel M, Shah S, Tramentozzi E, Brooks J, Bolaender A, Shrestha L, Stephani R, Finotti P, Leifer C, Li Z, Gewirth D, Taldone T, Chiosis G. 2015. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog, Grp94. J Med Chem 58:3922-3943.
Potuck AN, Weed BL, Leifer CA, Chu CC. 2015. Electrostatically self-assembled biodegradable microparticles from pseudoproteins and polysaccharide: fabrication, characterization and biological properties. Biomacromolecules 16:564-577.
Rosenthal JA, Juang C, Doody AM, Leung T, Mineta K, Feng DD, Wayne EC, Nishimura N, Leifer CA, DeLisa MP, Mendez S, Putnam D. 2014. Mechanistic insight into the Th1-biased immune response to recombinant subunit vaccines delivered by probiotic bacteria-derived outer membrane vessicles. PLoS One 9(11):e112802.
Singh A, Rahman T, Malik M, Hickey AJ, Leifer CA, Hazlett KRO, Sellati TJ. 2013. Discordant Results Obtained with Francisella tularensis during In Vitro and In Vivo Immunological Studies Are Attributable to Compromised Bacterial Structural Integrity. PLoS One 8:e58513.
Scalfone LK, Nel HJ, Gagliardo LF, Cameron JL, Al-Shokri S, Leifer CA, Fallon PG, Appleton JA. 2013. A prominent role for IL-33 in MyD88-dependent amplification of Th2 immunity and in controlling infection by a parasitic nematode. Infection and Immunity 81:1354-1363
Rose WA, K Sakamoto, CA Leifer. 2012. TLR9 is important for protection against intestinal damage and for intestinal repair. Scientific Reports 2:574.
Rose WA, K Sakamoto, CA Leifer. 2012. Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases. BioMed Central Immunology 13:41.
Knežević J, 10, Pavlinić D, Rose III WA, Leifer CA, Bendelja K, Gabrilovac J, Parcina M, Lauc G, Kubarenko AV, Petricevic B, Vrbanec D, Bulat-Kardum L, Bekeredjian-Ding I, Pavelić J, Dembić Z, Weber ANR. 2012. Functional consequences of rare TLR9 gene mutation R892W. J Biol Chem 287:24544-24553.
Brooks J, W Sun, G Chiosis, CA Leifer. 2012. Heat shock protein gp96 regulates TLR9 proteolytic processing and conformational stability. Biochem Biophys Res Comm. 421:780-784.
Chockalingam A, WA Rose II, M Hasan, C Ju, CA Leifer. 2012. Cutting Edge: A Toll-like receptor 9 cytoplasmic tyrosine motif is selectively required for proinflammatory cytokine production. Journal of Immunology 188:527-530.
Hasan M, C Ruksznis, Y Wang, CA Leifer. 2011. Negative regulation of TLR3 signaling by an antimicrobial peptide. Journal of Immunology, 187: 5653-5659. *Evaluated by Faculty of 1000, which reviews the top 2% of published articles in biology and medicine.
Leifer CA and R Dietert. 2011. Developmental immunotoxicology and innate immunity. Toxicological and Environmental Chemistry. 93: 1463-1485.
Chockalingam A, J Brooks, J Cameron, CA Leifer. 2011. Negative regulation of Signaling by a Soluble Form of Toll-like receptor 9. European Journal of Immunology 41:2176-2184. *Featured by the Journal and in the Cornell Chronicle.
Ju CJ, A Chockalingam, JL Lopez, CA Leifer. 2009. Intestinal epithelial cells respond directly to Toxoplasma gondii and secrete inflammatory mediators via TLR2. J Immunol 183:7420-7427.
Bowdish DME, K Sakamoto, S Mukhopadhyay, CA Leifer, K Tryvaggson, S Gordon, DG Russell. 2009. Macrophage receptor with collagenous structure binds mycobacterial trehalose dimycolate and in concert with CD14, initiates TLR2 signaling. PLOS Pathogens 5(6):e1000474.
Chockalingam A, JC Brooks, JL Lopez, LK Blum, CA Leifer. 2009. TLR9 traffics through the Golgi to localize to endolysosomes and respond to CpG DNA. Immunol Cell Biol 87:209-217.
Dubey JP,GV Velmurugana, A Chockalingam, HF Pena, L Nunes de Oliveira, CA Leifer, SM Gennari, LMG Bahia Oliveira, C Su. 2008. Genetic diversity of Toxoplasma gondii isolates from chickens from Brazil. Vet Parasitol 157:299-305.
Semnani RT, Goel P, CA Leifer, S Mostböck, H Sabzevari, TB Nutman. 2008. Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites. Blood 112: 1290-1298.
Leifer CA*, JC Brooks, K Hoelzer, JL Lopez, MN Kennedy, A Mazzoni, DM Segal. 2006. Cytoplasmic targeting motifs control localization of Toll-like receptor 9. J Biol Chem 281: 35585-35592.*This work was conceived and initiated as a postdoctoral fellow, but the bulk of the experiments and work was performed at Cornell with a Graduate Student (JCB), a rotation student (KH) and a technician (JLL). I served as the corresponding author.
Work performed prior to arrival at Cornell:
Mazzoni A, RP Siraganian, CA Leifer, DM Segal. 2006. Dendritic cell modulation by mast cells controls the Th1/Th2 balance in responding T cells. J Immunol 177: 3577-3581.
Wang ZY, D Yang, Q Chen, CA Leifer, DM Segal, SB Su, RR Caspi, ZO Howard, JJ Oppenheim. 2006. Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways. Exp Hematol 34:1115-1124.
Bafica, A., CA Scanga, CG Feng, CA Leifer, A Cheever, A Sher. 2005. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J Exp Med 202:17151724.
Leifer CA, MN Kennedy, A Mazzoni, CW Lee, MJ Kruhlak, DM Segal. 2004. TLR9 is localized in the ER prior to stimulation. J Immunol 173: 1179-1183.
Kennedy MN, GED Mullen, CA Leifer, CW Lee, A Mazzoni, KN Dileepan, DM Segal. 2004. A complex of soluble MD2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4. J Biol Chem 279: 34698-34704.
Bell JK, GED Mullen, CA Leifer, A Mazzoni, DR Davies, DM Segal. 2003. Leucine-rich repeats and pathogen recognition in Toll-like receptors. Trends Immunol 24: 528-533.
Huang LY, J Aliberti, CA Leifer, DM Segal, A Sher, DT Golenbock, B Golding. 2003. Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent. J Immunol 171: 1441-1446.
Leifer CA, D Verthelyi, DM Klinman. 2003. Heterogeneity in the human response to immunostimulatory CpG Oligodeoxynucleotides. J Immunotherapy 26: 313-319.
Mullen GE, MN Kennedy, A Visintin, A Mazzoni, CA Leifer, DR Davies, DM Segal. 2003. The role of disulfide bonds in the assembly and function of MD-2. Proc Natl Acad Sci USA 100: 3919-3924.
Mazzoni A, CA Leifer, GE Mullen, MN Kennedy, DM Klinman, DM Segal. 2003. Cutting Edge: Histamine Inhibits IFN-alpha Release from Plasmacytoid Dendritic Cells. J Immunol 170: 2269-2273.
Biragyn A, PA Ruffini, CA Leifer, E Klyushnenkova, A Shakhov, O Chertoc, AK Shirakawa, JM Farber, DM Segal, JJ Oppenheim, LW Kwak. 2002. Toll-Like receptor 4-dependent activation of dendritic cells by betadefensin 2. Science298: 1025-1029.
Klinman DM, F Takeshitsa, I Gursel, C Leifer, KJ Ishii, D Verthelyi, M Gursel. 2002. CpG DNA: Recognition by and activation of monocytes. Microbes Infect 4: 897-901.
Takeshita F*, CA Leifer*, I Gursel, KJ Ishii, S Takeshita, M Gursel, DM Klinman. 2001. Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J Immunol 167: 3555-3558 *co-first author.
Under maiden name Byrd:
Byrd-Leifer CA, EF Block, K Takeda, S Akira, A Ding. 2001. The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol. Eur J Immunol 31: 2448-2457.
Byrd C, W Bornmann, H Erdjument-Bromage, P Tempst, N Pavletich, N Rosen, C Nathan, A Ding. 1999. Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide. Proc Natl Acad Sci USA 96: 5645-5650.
Zizi M, C Byrd, R Boxus, and M Colombini. 1998. The voltage-gating process of the voltage-dependent anion channel is sensitive to ion flow. Biophysical J 75: 704-713.
Gulbins E, R Bissonnette, A Mahboubi, S Martin, W Nishioka, T Brunner, G Baier, G Baier-Bitterlich, C Byrd, F Lang, R Kolesnick, A Altman, and D Green. 1995. Fas-induced apoptosis is mediated via a ceramideinitiated RAS signaling pathway. Immunity 2: 341-351.
Gruber EJ, Aygun AY, Leifer CA.. Macrophage uptake of oxidized and acetylated low-density lipoproteins and generation of reactive oxygen species are regulated by linear stiffness of the growth surface. 2021 PLoS One. Dec 16;16(12):e0260756. doi: 10.1371/journal.pone.0260756.
Gruber EJ, Leifer CA. Molecular regulation of TLR signaling in health and disease: mechano-regulation of macrophages and TLR signaling.
2020 Innate Immun. Jan;26(1):15-25. doi: 10.1177/1753425919838322.
Mosquera MJ, Kim S, Zhou H, Jing TT, Luna M, Guss JD, Reddy P, Lai K, Leifer CA, Brito IL, Hernandez CJ, Singh A. Immunomodulatory nanogels overcome restricted immunity in a murine model of gut microbiome-mediated metabolic syndrome. 2019. Sci Adv. 5(3):eaav9788. doi: 10.1126/sciadv.aav9788.
Li S, , Walter WA, Chassing B, Zhang B, Shi Q, Waters J, Gewirtz AT, Leifer CA ,Ley RE. Gut microbiota influence B cell function in a TLR5-dependent manner. 2019 BioRXiV doi: doi.org/10.1101/537894.
Singel KL, Grzankowski KS, Khan ANMNH, Grimm MJ, D'Auria AC, Morrell K, Eng KH, Hylander B, Mayor PC, Emmons TR, Lénárt N, Fekete R, Környei Z, Muthukrishnan U, Gilthorpe JD, Urban CF, Itagaki K, Hauser CJ, Leifer C, Moysich KB, Odunsi K, Dénes Á, Segal BH. Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer. 2019 Br J Cancer. 120(2):207-217. doi: 10.1038/s41416-018-0339-8.
Gruber, EJ, Heyward C, Cameron, JL, Leifer, CA. TLR signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled coil kinase (ROCK1/2). 2018 Int Immunol. 30(6):267-278. doi: 10.1093/intimm/dxy027.
Heyward C, Sones J, Lob H, Yeun L, Abbott K, Huang W, Begun Z, Butler S, August A, Leifer C, Davisson RL. 2017. The decídua of BPH/5 preeclamptic-like mice exhibits an exaggerated inflammatory response during early pregnancy, J Repro Immunology 120:27-33.
Watkins HC, Rappazzo CG, Higgins JS, Sun X, Brock N, Chau A, Misra A, Cannizzo JP, King MR, Maines TR, Leifer CA, Whittaker GR, DeLisa MP, Putnam D. 2017 Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection. Mol Ther. S1525-0016(17)30016-3.
Phan TL, Pritchett JC, Leifer CA, Zerr DM, Koelle DM, Di Luca D, Lusso P. HHV-6B infection, T-cell reconstitution, and graft-vs-host disease after hematopoietic stem cell transplantation. 2018 Bone Marrow Transplant. 53(12):1508-1517 doi: 10.1038/s41409-018-0225-2.
Londono R, Dziki JL, Haljasmaa E, Turner NJ, Leifer CA, Badylak SF. The effect of cell debris within biologic scaffolds upon the macrophage response. 2017 J Biomed Mater Res A. 105(8):2109-2118.
Heyward CY, Sones JL, Lob HE, Yuen LC, Abbott KE, Huang W, Begun ZR, Butler SD, August A, Leifer CA, Davisson RL. The decidua of preeclamptic-like BPH/5 mice exhibits an exaggerated inflammatory response during early pregnancy. 2017 J Reprod Immunol. 120:27-33. .
Watkins HC, Rappazzo CG, Higgins JS, Sun X, Brock N, Chau A, Misra A, Cannizzo JP, King MR, Maines TR, Leifer CA, Whittaker GR, DeLisa MP, Putnam D. Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection. 2017 Mol Ther. 25(4):989-1002.
CA Leifer. Dendritic cells in host response to biologic scaffolds. 2017 Semin Immunol. 29:41-48.
Leifer CA, Medvedev AE. Molecular mechanisms of regulation of Toll-like receptor signaling. 2016 J Leukoc Biol. 2016 100(5):927-941.
Sinha SS, Cameron JL, Brooks JC, Leifer CA. Complex Negative Regulation of TLR9 by Multiple Proteolytic Cleavage Events. J Immunol. 2016 Aug 15;197(4):1343-52.
Hasan M, Gruber E, Cameron J, Leifer CA. TLR9 stability and signaling are regulated by phosphorylation and cell stress. J Leukoc Biol. 2016 Sep;100(3):525-33.
Rappazzo CG, Watkins HC, Guarino CM, Chau A, Lopez JL, DeLisa MP, Leifer CA, Whittaker GR, Putnam D. 2016. Recombinant M2e outer membrane vessicle vaccines protect against lethal influenza A challenge in BALB/c mice. Vaccine 34:1252-1258.
Patel H, Patel P, Ochiana S, Yan P, Sun W, Patel M, Shah S, Tramentozzi E, Brooks J, Bolaender A, Shrestha L, Stephani R, Finotti P, Leifer C, Li Z, Gewirth D, Taldone T, Chiosis G. 2015. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog, Grp94. J Med Chem 58:3922-3943.
Potuck AN, Weed BL, Leifer CA, Chu CC. 2015. Electrostatically self-assembled biodegradable microparticles from pseudoproteins and polysaccharide: fabrication, characterization and biological properties. Biomacromolecules 16:564-577.
Rosenthal JA, Juang C, Doody AM, Leung T, Mineta K, Feng DD, Wayne EC, Nishimura N, Leifer CA, DeLisa MP, Mendez S, Putnam D. 2014. Mechanistic insight into the Th1-biased immune response to recombinant subunit vaccines delivered by probiotic bacteria-derived outer membrane vessicles. PLoS One 9(11):e112802.
Singh A, Rahman T, Malik M, Hickey AJ, Leifer CA, Hazlett KRO, Sellati TJ. 2013. Discordant Results Obtained with Francisella tularensis during In Vitro and In Vivo Immunological Studies Are Attributable to Compromised Bacterial Structural Integrity. PLoS One 8:e58513.
Scalfone LK, Nel HJ, Gagliardo LF, Cameron JL, Al-Shokri S, Leifer CA, Fallon PG, Appleton JA. 2013. A prominent role for IL-33 in MyD88-dependent amplification of Th2 immunity and in controlling infection by a parasitic nematode. Infection and Immunity 81:1354-1363
Rose WA, K Sakamoto, CA Leifer. 2012. TLR9 is important for protection against intestinal damage and for intestinal repair. Scientific Reports 2:574.
Rose WA, K Sakamoto, CA Leifer. 2012. Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases. BioMed Central Immunology 13:41.
Knežević J, 10, Pavlinić D, Rose III WA, Leifer CA, Bendelja K, Gabrilovac J, Parcina M, Lauc G, Kubarenko AV, Petricevic B, Vrbanec D, Bulat-Kardum L, Bekeredjian-Ding I, Pavelić J, Dembić Z, Weber ANR. 2012. Functional consequences of rare TLR9 gene mutation R892W. J Biol Chem 287:24544-24553.
Brooks J, W Sun, G Chiosis, CA Leifer. 2012. Heat shock protein gp96 regulates TLR9 proteolytic processing and conformational stability. Biochem Biophys Res Comm. 421:780-784.
Chockalingam A, WA Rose II, M Hasan, C Ju, CA Leifer. 2012. Cutting Edge: A Toll-like receptor 9 cytoplasmic tyrosine motif is selectively required for proinflammatory cytokine production. Journal of Immunology 188:527-530.
Hasan M, C Ruksznis, Y Wang, CA Leifer. 2011. Negative regulation of TLR3 signaling by an antimicrobial peptide. Journal of Immunology, 187: 5653-5659. *Evaluated by Faculty of 1000, which reviews the top 2% of published articles in biology and medicine.
Leifer CA and R Dietert. 2011. Developmental immunotoxicology and innate immunity. Toxicological and Environmental Chemistry. 93: 1463-1485.
Chockalingam A, J Brooks, J Cameron, CA Leifer. 2011. Negative regulation of Signaling by a Soluble Form of Toll-like receptor 9. European Journal of Immunology 41:2176-2184. *Featured by the Journal and in the Cornell Chronicle.
Ju CJ, A Chockalingam, JL Lopez, CA Leifer. 2009. Intestinal epithelial cells respond directly to Toxoplasma gondii and secrete inflammatory mediators via TLR2. J Immunol 183:7420-7427.
Bowdish DME, K Sakamoto, S Mukhopadhyay, CA Leifer, K Tryvaggson, S Gordon, DG Russell. 2009. Macrophage receptor with collagenous structure binds mycobacterial trehalose dimycolate and in concert with CD14, initiates TLR2 signaling. PLOS Pathogens 5(6):e1000474.
Chockalingam A, JC Brooks, JL Lopez, LK Blum, CA Leifer. 2009. TLR9 traffics through the Golgi to localize to endolysosomes and respond to CpG DNA. Immunol Cell Biol 87:209-217.
Dubey JP,GV Velmurugana, A Chockalingam, HF Pena, L Nunes de Oliveira, CA Leifer, SM Gennari, LMG Bahia Oliveira, C Su. 2008. Genetic diversity of Toxoplasma gondii isolates from chickens from Brazil. Vet Parasitol 157:299-305.
Semnani RT, Goel P, CA Leifer, S Mostböck, H Sabzevari, TB Nutman. 2008. Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites. Blood 112: 1290-1298.
Leifer CA*, JC Brooks, K Hoelzer, JL Lopez, MN Kennedy, A Mazzoni, DM Segal. 2006. Cytoplasmic targeting motifs control localization of Toll-like receptor 9. J Biol Chem 281: 35585-35592.*This work was conceived and initiated as a postdoctoral fellow, but the bulk of the experiments and work was performed at Cornell with a Graduate Student (JCB), a rotation student (KH) and a technician (JLL). I served as the corresponding author.
Work performed prior to arrival at Cornell:
Mazzoni A, RP Siraganian, CA Leifer, DM Segal. 2006. Dendritic cell modulation by mast cells controls the Th1/Th2 balance in responding T cells. J Immunol 177: 3577-3581.
Wang ZY, D Yang, Q Chen, CA Leifer, DM Segal, SB Su, RR Caspi, ZO Howard, JJ Oppenheim. 2006. Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways. Exp Hematol 34:1115-1124.
Bafica, A., CA Scanga, CG Feng, CA Leifer, A Cheever, A Sher. 2005. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J Exp Med 202:17151724.
Leifer CA, MN Kennedy, A Mazzoni, CW Lee, MJ Kruhlak, DM Segal. 2004. TLR9 is localized in the ER prior to stimulation. J Immunol 173: 1179-1183.
Kennedy MN, GED Mullen, CA Leifer, CW Lee, A Mazzoni, KN Dileepan, DM Segal. 2004. A complex of soluble MD2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4. J Biol Chem 279: 34698-34704.
Bell JK, GED Mullen, CA Leifer, A Mazzoni, DR Davies, DM Segal. 2003. Leucine-rich repeats and pathogen recognition in Toll-like receptors. Trends Immunol 24: 528-533.
Huang LY, J Aliberti, CA Leifer, DM Segal, A Sher, DT Golenbock, B Golding. 2003. Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent. J Immunol 171: 1441-1446.
Leifer CA, D Verthelyi, DM Klinman. 2003. Heterogeneity in the human response to immunostimulatory CpG Oligodeoxynucleotides. J Immunotherapy 26: 313-319.
Mullen GE, MN Kennedy, A Visintin, A Mazzoni, CA Leifer, DR Davies, DM Segal. 2003. The role of disulfide bonds in the assembly and function of MD-2. Proc Natl Acad Sci USA 100: 3919-3924.
Mazzoni A, CA Leifer, GE Mullen, MN Kennedy, DM Klinman, DM Segal. 2003. Cutting Edge: Histamine Inhibits IFN-alpha Release from Plasmacytoid Dendritic Cells. J Immunol 170: 2269-2273.
Biragyn A, PA Ruffini, CA Leifer, E Klyushnenkova, A Shakhov, O Chertoc, AK Shirakawa, JM Farber, DM Segal, JJ Oppenheim, LW Kwak. 2002. Toll-Like receptor 4-dependent activation of dendritic cells by betadefensin 2. Science298: 1025-1029.
Klinman DM, F Takeshitsa, I Gursel, C Leifer, KJ Ishii, D Verthelyi, M Gursel. 2002. CpG DNA: Recognition by and activation of monocytes. Microbes Infect 4: 897-901.
Takeshita F*, CA Leifer*, I Gursel, KJ Ishii, S Takeshita, M Gursel, DM Klinman. 2001. Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J Immunol 167: 3555-3558 *co-first author.
Under maiden name Byrd:
Byrd-Leifer CA, EF Block, K Takeda, S Akira, A Ding. 2001. The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol. Eur J Immunol 31: 2448-2457.
Byrd C, W Bornmann, H Erdjument-Bromage, P Tempst, N Pavletich, N Rosen, C Nathan, A Ding. 1999. Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide. Proc Natl Acad Sci USA 96: 5645-5650.
Zizi M, C Byrd, R Boxus, and M Colombini. 1998. The voltage-gating process of the voltage-dependent anion channel is sensitive to ion flow. Biophysical J 75: 704-713.
Gulbins E, R Bissonnette, A Mahboubi, S Martin, W Nishioka, T Brunner, G Baier, G Baier-Bitterlich, C Byrd, F Lang, R Kolesnick, A Altman, and D Green. 1995. Fas-induced apoptosis is mediated via a ceramideinitiated RAS signaling pathway. Immunity 2: 341-351.